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Seahawks vs. Lions prediction, odds, spread, injuries, trends for NFL Week 2

Breaking down a full betting preview for the Detroit Lions Week 2 matchup against the Seattle Seahawks.

By Iain MacMillan

Sep 7, 2023; Kansas City, Missouri, USA; Detroit Lions wide receiver Amon-Ra St. Brown (14)
Sep 7, 2023; Kansas City, Missouri, USA; Detroit Lions wide receiver Amon-Ra St. Brown (14) / Jay Biggerstaff-USA TODAY Sports
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The Detroit Lions had a dream start to their 2023 season, upsetting the defending champs on opening night. After an offseason of nothing but hype, they delivered in a big way.

Now, they're coming off a mini-BYE week to take on the Seattle Seahawks, who were dominated by the Los Angeles Rams are 5.5-point favorites.

Can the Lions build on their hot start?

I'm going to break down my best bet for the game in this article, but if you want the rest of my picks for Week 2, check out the latest edition of the "Road to 272 Bets."

If you plan on betting on this weekend's action, I'd recommend signing up for Caesars Sportsbook. For a limited time, new users will be given $250 in bonus bets after they place their first $50 wager! So, wager on the Lions this week and get $250 in bonus bets. It's really that easy! Just click the link below to take advantage of this offer.

Now, let's dive into this Week 2 showdown.

Seahawks vs. Lions odds, spread, and total

Seahawks vs. Lions betting trends

  • Seahawks are 1-9 against the spread in their last 10 games
  • The UNDER is 5-1 in the Seahawks' last six games
  • Seahawks are 4-1 ATS in their last five games against the Lions
  • Seahawks are 1-4 ATS in their last five road games
  • Seahawks are 0-7 ATS in their last even games against NFC opponents
  • Lions are 10-1 ATS in their last 11 games

Seahawks vs. Lions injury reports

Seattle Seahawks Injury Report

  • Devon Witherspoon - CB - Questionable
  • Jamal Adams - S - Questionable
  • Charles Cross - OT - Questionable (turf toe)
  • Abraham Lucas - OT - Questionable (knee)

Detroit Lions Injury Report

  • Emmanuel Moseley - CB - Questionable
  • Brian Branch - S - Questionable (cramps)

Seahawks vs. Lions how to watch

  • Date: Sunday, Sept. 17
  • Game Time: 1:00p.m. EST
  • Venue: Ford Field
  • How to Watch (TV): FOX
  • Seattle Seahawks Record: 0-1
  • Detroit Lions Record: 1-0

Seattle Seahawks key players to watch

Seattle Seahawks

Geno Smith: Just one year removed from finishing in the top 10 in MVP voting and winning Comeback Player of the Year, Geno Smith struggled in his 2023 opener against the Rams. He completed just 16-of-26 passes for 112 yards and one touchdown. If the Seahawks wants to return to the playoffs, he'll need to step it up as the season goes on.

Detroit Lions

Amon-Ra St. Brown: The Rams receivers torched the Seahawks secondary in Week 1. Both Tutu Atwell and Puka Nacua surpassed 100 yards in their win against Seattle. If those two guys can do that against the Seahawks, imagine what Amon-Ra St. Brown can do. He racked up 71 yards and a touchdown on six receptions on opening night and he's poised to be one of the highest producing receivers in the NFL this season.

Seahawks vs. Lions prediction and pick

I picked the Rams to upset the Seahawks last week and it wasn't just because I thought the Rams were better than people thought. More than anything, I'm a lot lower on the Seahawks than the public opinion of them. The Seahawks had a lot of things go right for them last season that resulted in a postseason berth. Now, it's a new season and I expect regression from them.

Meanwhile, I was impressed by the progress seemingly made by the Lions defense in the offseason. Sure, they played against a Travis Kelce-less Chiefs team on opening night, but they still got the job done and kept Patrick Mahomes in check.

I think the Lions will roll the Seahawks on Sunday.

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!

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