Lions vs. Packers prediction, odds, spread, injuries, trends for NFL Week 4

The Lions are in a great spot to pick up an important division win.
Detroit Lions tight end Sam LaPorta (87) scores a touchdown.
Detroit Lions tight end Sam LaPorta (87) scores a touchdown. / Kirthmon F. Dozier / USA TODAY NETWORK

The NFC North has two teams at 2-1 and two at 0-3, but luckily for NFL fans the teams that are 2-1 will face off on Thursday Night Football. 

The Detroit Lions hit the road this week to play the Green Bay Packers, who are coming off a comeback win over the New Orleans Saints in Week 3. 

Detroit handled the Atlanta Falcons in Week 3, and the team’s defense has been one of the bigger surprises so far in 2023. Detroit ranks fifth in the NFL in yards per play allowed. 

For more NFL Week 4 picks, check out BetSided NFL betting analyst Iain MacMillan's best bet for every game in his "Road to 272" bets this season.

This game could have huge implications for how the NFC North plays out this season, so why don’t we break down the odds and a prediction for it? 

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Lions vs. Packers odds, spread and total for NFL Week 4

Lions vs. Packers betting trends

  • The Packers are 3-0 against the spread this season.
  • The Lions are 2-1 against the spread this season.
  • The Lions are 25-12 ATS since Dan Campbell was named head coach, the best mark in the NFL.
  • The OVER is 2-1 in the Packers’ three games this season.
  • The UNDER is 2-1 in the Lions’ three games this season.

Lions vs. Packers injury reports

Detroit Lions injury report

  • Taylor Decker – questionable
  • Emmanuel Moseley – questionable
  • David Montgomery – questionable
  • Dan Skipper – questionable
  • Jonah Jackson – questionable
  • Kerby Joseph – questionable
  • Matt Nelson – questionable
  • Jason Cabinda – questionable

Green Bay Packers injury report

  • Aaron Jones – questionable
  • Christian Watson – questionable
  • Elgton Jenkins – questionable
  • David Bakhtiari – questionable
  • De’Vondre Campbell – questionable
  • Rashan Gary – questionable
  • Carrington Valentine – questionable
  • Zach Tom – questionable
  • Zayne Anderson – questionable

Lions vs. Packers how to watch

  • Date: Thursday, Sept. 28
  • Game Time: 8:15 p.m. EST
  • Venue: Lambeau Field
  • How to Watch (TV): Amazon Prime
  • Detroit Lions Record: 2-1
  • Green Bay Packers Record: 2-1

Lions vs. Packers key players to watch

Detroit Lions

Sam LaPorta: The rookie tight end caught his first touchdown in Week 3, making eight catches for 84 yards in the process. LaPorta has made at least five catches in every game this season, and he is clearly one of the top options in this offense. Green Bay will need to keep him in check. 

Jahmyr Gibbs: David Montgomery is nursing a thigh injury, so Gibbs may get another week as the lead back for Detroit. Last week, he had 17 carries for 80 yards and made one catch. The rookie running back is a dynamic weapon, and should be a focal point of the offense. 

Green Bay Packers

Jordan Love: Which Jordan Love will show up in Week 4? Love is completing just 53.1 percent of his passes this season, but he did lead the team back from a 17-0 deficit against the New Orleans Saints in Week 3. He’s going to have to be sharper against the Lions team which ranks fifth in the NFL in yards per play allowed. 

Lions vs. Packers prediction and pick

I have to take the Lions to win this game for several reasons. 

Sure, the Packers are 2-1, but they have some serious faults on offense with Jordan Love completing less than 54 percent of his passes and the team averaging just 3.4 yards per carry, the seventh-fewest in the NFL. 

Where does the offense end up coming from if Love doesn’t hit a few big passing plays? 

Plus, the Packers could be without Aaron Jones (hamstring) and Christian Watson (hamstring) again because this is a short week. It’s possible one plays, but even if they do it’s likely that they’ll be operating at less than 100 percent. 

Detroit’s defense has really flipped the script from last season, shutting down Atlanta in Week 3 even without Chauncey Gardner-Johnson (injured reserve). 

The team also ranks seventh in the NFL in yards per play on offense this season and has been elite against the spread under Dan Campbell. 

I’m not even going to mess around with the 1.5 points in this game, just give me Detroit to win outright. 

Game odds refresh periodically and are subject to change.

Find Peter Dewey's betting record here.