Lions vs. Chargers prediction, odds, spread, injuries, trends for NFL Week 10

Lions wide receiver Amon-Ra St. Brown runs the ball against the Raiders during the first half on
Lions wide receiver Amon-Ra St. Brown runs the ball against the Raiders during the first half on / Kirthmon F. Dozier / USA TODAY NETWORK

The Detroit Lions are coming off their BYE week at 6-2, sitting as the No. 2 seed in the NFC. They have a tough challenge ahead of them in Week 10 as they head to the West Coast to take on the Los Angeles Chargers, who seem to be hitting their stride.

In this article, I'm going to break down everything you need to know to bet on this game.

If you want my best bet for every game on the Week 10 slate, you can find them in the latest edition of the Road to 272 Bets here.

If you want to place a bet on this Sunday's game against the Chargers, you should do so at Caesars Sportsbook because for a limited time, if you click the link below to sign up for an account, you'll get your first bet on Caesars up to $1,000!

Bet at Caesars now!

Lions vs. Chargers odds, spread, and total

Lions vs. Chargers betting trends

  • Lions are 5-1 ATS in their last six games
  • Lions are 2-5 ATS in their last seven games vs. Chargers
  • Lions are 4-1 ATS in their last five road games
  • The UNDER is 6-0 in the Chargers' last six games
  • The UNDER is 9-1 in the Chargers' last 10 games vs. NFC North opponents
  • Chargers are 4-1 ATS in their last five games played in November

Lions vs. Chargers injury reports

Detroit Lions injury report

  • David Montgomery - RB - Questionable
  • C.J. Gardner-Johnson - S - IR

Los Angeles Chargers injury report

  • Joshua Palmer - WR - IR
  • Raheem Layne - S - IR

Lions vs. Chargers how to watch

  • Date: Sunday, November 12
  • Game Time: 4:05 pm EST
  • Venue: SoFi Stadium
  • How to Watch (TV): CBS
  • Detroit Lions Record: 6-2
  • Los Angeles Chargers Record: 4-4

Lions vs. Chargers key players to watch

Detroit Lions

Amon-Ra St. Brown: The biggest weakness on the Chargers is their secondary, which means Amon-Ra St. Brown is set up for a monster game. The Chargers are allowing 7.2 yards per pass attempt this season, which ranks 30th in the NFL. Target St. Brown in your DFS lineups.

Los Angeles Chargers

Quentin Johnson Jr.: With no Mike Williams or Joshua Palmer, the pressure to be the No. 2 receiver on the Chargers falls on the shoulders of Quentin Johnston. He hasn't played great so far this season, but Los Angeles needs him to sign up sooner rather than later.

Lions vs. Chargers prediction and pick

The Chargers are coming off two big wins against the Bears and Jets, but let's not forget this team has a ton of issues defensively that are exploited when they play good teams. They're one of the worst teams in the NFL when it comes to opponent yards per pass attempt, which is going to be a big issue for them against a stout Lions pass attack coming off a bye.

The offenses for these two teams are extremely comparable, but the Lions defense is league's above the Chargers' this year. Detroit comes in at 7th in opponent EPA per play while the Chargers are 29th. That's going to prove to be the difference maker in this one.

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!