Detroit Lions best bets vs. Buffalo Bills Week 12

Nov 20, 2022; East Rutherford, New Jersey, USA; Detroit Lions running back Jamaal Williams (30) scores a rushing touchdown during the first half against the New York Giants at MetLife Stadium. Mandatory Credit: Vincent Carchietta-USA TODAY Sports
Nov 20, 2022; East Rutherford, New Jersey, USA; Detroit Lions running back Jamaal Williams (30) scores a rushing touchdown during the first half against the New York Giants at MetLife Stadium. Mandatory Credit: Vincent Carchietta-USA TODAY Sports

As you look to start your Week 12 betting action with a Thanksgiving Day bounty, here are three best bets for the Detroit Lions against the Buffalo Bills.

Before getting into the best bets for the Detroit Lions in Week 12, let’s see how Week 11’s best bets did.

WR Amon-Ra St. Brown, Anytime touchdown (+155, FanDuel; +145, DraftKings): No touchdown
RB Jamaal Williams, 75-plus rushing yards (+170, DraftKings): 64 rushing yards
QB Jared Goff, Over 1.5 passing touchdowns (+135, DraftKings; +134, FanDuel): No touchdowns

Good thing it’s a short week.

The Lions are on a three-game winning streak, but a short week means the positive feelings have to be set aside to quickly re-focus for a game. Oh, and they’ll be facing arguably the best team in the NFL in the Buffalo Bills.

Via the sportsbook noted, here are three best bets for the Lions in Week 12 against the Bills.

Detroit Lions best bets vs. Bills in Week 12

Lions, +9.5 (-104, FanDuel; -110, DraftKings)

The Lions are a 9.5-point underdog for Thursday’s game, which isn’t terribly surprising. But the Bills have only exceeded that margin in one of their last three wins, and that one (27-17 over the Green Bay Packers in Week 8) was barely. The Browns needed a late touchdown in Week 11 to make that an eight-point win for Buffalo, but when it comes to betting spreads getting there is all that matters.

It may take a backdoor cover with a late score for the Lions. But 9.5 points is too rich a spread, and it’s begging for bets on Detroit to cover.

DE Aidan Hutchinson, Over 0.75 sacks (+160, DraftKings)

Hutchinson has gone without a sack in three of his last four games. But in general, it’s not because he’s not winning or putting pressure on the quarterback. The Bills’ offensive line is solid and Josh Allen is not easy to take down, but I still like Hutchinson for at least one sack on Thursday.

RB Jamaal Williams, Parlay? (Over 13.5 rushing attempts, -130, DraftKings; 75-plus rushing yards, +265, DraftKings)

The Bills, outside of some slippage in the weeks before Week 11 against the Browns, have been strong against the run this season. But Williams should have no trouble clearing 13.5 rushing attempts on Thursday, as the Lions try to control the clock, and based on pure volume 75 or more rushing yards becomes a viable bet at very nice plus-money if it cashes. This works as separate bets, or as a “build your own” parlay.

Note: Game odds refresh periodically and are subject to change.

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